4.1.2: Official Definition
A persistent transient failure is one in which the message as sent is valid, but persistence of some temporary condition has caused abandonment or delay of attempts to send the message. If this code accompanies a delivery failure report, sending in the future may be successful.
The destination system specified in the address does not exist or is incapable of accepting mail. For Internet mail names, this means the address portion to the right of the "@" is invalid for mail. This code is only useful for permanent failures.