5.2.1: Official Definition
5.X.X
[RFC3463] (Standards Track) from the The Internet Engineering Task Force (IETF) definition for codes that start with 5.X.X:
A permanent failure is one which is not likely to be resolved by resending the message in the current form. Some change to the message or the destination must be made for successful delivery.
X.2.1
[RFC3463] (Standards Track) from the The Internet Engineering Task Force (IETF) definition for codes that end with X.2.1:
The mailbox exists, but is not accepting messages. This may be a permanent error if the mailbox will never be re-enabled or a transient error if the mailbox is only temporarily disabled.