5.1.2: Official Definition
5.X.X
[RFC3463] (Standards Track) from the The Internet Engineering Task Force (IETF) definition for codes that start with 5.X.X:
A permanent failure is one which is not likely to be resolved by resending the message in the current form. Some change to the message or the destination must be made for successful delivery.
X.1.2
[RFC3463] (Standards Track) from the The Internet Engineering Task Force (IETF) definition for codes that end with X.1.2:
The destination system specified in the address does not exist or is incapable of accepting mail. For Internet mail names, this means the address portion to the right of the "@" is invalid for mail. This code is only useful for permanent failures.